Leveraging a natural Defense Mechanism

Alpha-2-Macroglobulin (A2M) is naturally produced by the liver and acts as a Miracle Molecule™. But due to its large size, complex structure, and the avascular design of the joint, A2M is unable to enter affected joints spaces in large enough quantities. An incredible breakthrough in orthopedic science and research, ALPHA2ACTIVE™ presents an option against destructive enzymes causing joint degradation that the body is unable to defend against fully on it’s own.

Diagram of a drug process showing concentrated alpha-2M injected at joint site, capturing harmful enzymes, which are then excreted from the system with bonded alpha-2M and protease.

**The 1st and Only Patented A2M CONCENTRATION System**

Not all “A2M” products are created equal—and it’s important to know the difference. ALPHA2ACTIVE™ isolates and concentrates A2M from patients’ own blood through a proprietary, patented filtration process—achieving up to six times the concentration.

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Diagram illustrating the centrifugation process of drawn blood, showing separation into plasma, white blood cells, and red blood cells, and the alpha2Active filtration process for concentrated alpha-2 macroglobulin serum collection, with components like a parastaltic pump and waste collection bag.

Redefine Regenerative Medicine

Scientific research article titled 'α2-Macroglobulin Autologous Protease Inhibition Technology' by Jason M. Cuéllar and Vanessa Gabovsky Cuéllar, with keywords, key points, introduction, author information, and publication details visible.

A2-Macroglobulin Autologous Protease Inhibition Technology

Research article titled "Intradiscal Injection of Autologous Alpha-2- Macrogobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients" authored by Pasquale X. Montsano MD, Jason M. Cuellar MD, PhD, Gaetano J. Scuderi MD, published in the Orthopedics and Rheumatology journal.

Intradiscal Injection of an Autologous Alpha-2-Macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients

Scientific research article titled 'Identification of alpha-2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis' with authors Shaowei Wang, Xiaochun Wei, Jingming Zhou, and others, published in Arthritis & Rheumatology.

Identification of A2M as a Master Inhibitor of Cartilage-Degrading Factors that Attenuates the Progression of Posttraumatic Osteoarthritis

Scan of a scientific journal article titled "α2-Macroglobulin Is a Novel Substrate for ADAMTS-4 and ADAMTS-5 and Represents an Endogenous Inhibitor of These Enzymes." The text includes authors, publication details, and an abstract discussing the research on α2-Macroglobulin and its role in cartilage and enzyme inhibition. The layout features a header, columns of dense text, and a small section of references at the bottom.

A2-Macroglobulin Is a Novel Substrate for ADAMTS-4 and ADAMTS-5 and Represents an Endogenous Inhibitor of These Enzymes*

ALPHA2ACTIVE™ in Action

ALPHA2ACTIVE™ Kit

Unlike hemoconcentrators or generic protein concentrators, ALPHA2ACTIVE™ utilizes patented filtration technology to harness authentic Alpha-2-Macroglobulin (A2M) both precisely and effectively. A2M can be collected and concentrated through 3 simple steps that come in a convenient kit form for providers in the USA.

Box labeled CAREstream America ALPHA 2 ACTIVE PRP Processing Kit on a black background.

Collect → Centrifuge → CONCENTRATE

Why your peers choose ALPHA2ACTIVE™

"Everyone is going to be getting A2M therapy. It's like anti-aging therapy for your joints."
Dr. Gaetano Scuderi | Jupiter, FL
"It has become a valuable option in the conservative care of many patients and the results have exceeded my expectations."
Dr. Stephen W. Etheredge | Baton Rouge, LA
“It’s been absolutely amazing for my patient.”
Dr. Jason M. Cuéllar | Palm Beach, FL

Keep Your Patients Moving. Discover ALPHA2ACTIVE™!

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